Run linux. Virus \ malware problem solved.
Avast works great.
Get a hacked version of Deepfreeze you can usually find it on btjunkie or thepiratebay with a crack. It keeps things from being saved to the computer. So if something fucks up. Reboot the computer. Tada good as new.
Honestly with most virus's its almost better to format and re-install. Seeing as most the time the stuff you wanna keep is infected. Just have some fast internet so you can download anything important you may have lost.
Secondly, for things that are REALLY important. Make hard copies of them. IE burning them on dvd's that way if you have really really important documents that you couldn't bare to lose. You wont have to worry about that. Or look into an online backup solution. They are rather cheap anymore.
Flash drives can be infected with a virus if it comes into contact with an infected computer. You cant infect a burnt dvd, unless the files you burnt onto it were already infected. Blank dvd's and cds are quite cheap if stuff changes just burn a new cd\dvd.
Problem solved.
I seen it mentioned here before. A lot of the newer malware infects the browser settings using a proxy server to redirect you to a strange webpage. Usually trying to get you to buy this "antivirus" software that will remove the malware. Its not a virus, its just shit this company made that paying 30$ will give you the stuff to remove it.
Boot into safemode with network support download antivirus software. Run antivirus. If still having problems. Format and re-install.