The thing to think about is each runner carries 2 cylinders worth of gasses, but each fires 180* from each other so they won't fight for "room" like a mini-ram or log. Most manifolds use 1.5" pipe, which is closer to 1.6" ID, for each runner. That's a cross section of ~2 sq". Something with a 2" ID would be over 3 sq", and more than enough for most setups.
I'd recommend the 4-2-1 ebay header. Mine, the one at the top with $20 worth of homeboy depot fittings, sucked in terms of flow. I was lazy and didn't remove the threads, nor did I open up the stock manifold outlets. Worst was the bolts, they always came loose. If you use studs/nugs, put a weld bead at the other side of the stud to keep it from loosening, and use castle nuts w/cotter pins through holes in the studs to keep shit tight. No form of lock washer or lock nut will hold with that heat. At least nothing that costs less than $30 per washer.