NOT FOR ME, for my sister's family.
I was about to say...
Uhm, I haven't paid attention to the RAV4 since it came out so I still have a mental image of the 1G version that's too fucking small for use as a family mobile.
I, also, would go with the Escape over the RAV4. If they are buying new they are under warranty for a while so you can take ratcityrex's $0.02 with a grain of salt - I'd still do some serious research on the subject, though. There's a lot of stuff that sucks to wrench on, especially your first time around on the job, and most modern automagics will fail at some point even if you regularly change fluid and filter UNLIKE 80% of owners. Especially if they are the sort who own something the "usual" 3-5 years and then flip it, I wouldn't worry too much. Just make sure it's not a total piece of shit.
I'd also toss in a vote for a NATURALLY ASPIRATED Subaru, and put it on equal footing with the Escape. Those are fun vehicles to drive, they do really well in rougher terrain than any woman with kids will seek out. The turbo units are maintenance pieces, though... they are fine stock IF you are anal about servicing them, but most men/all women never change oil regularly and drive shit into the ground when they should be calling a tow truck. Plus, it's an excuse to buy a Tactrix 2.0 cable and you can disable those silly CELs when the vehicle has a few miles on it and it's time to pass emissions.