low compression = safer for higher boost numbers.
For reference, first gen DSM's run right around 7.8:1 compression from the factory, and they take some pretty nasty boost levels out of the box.
Higher compression will obviously make better power on the same boost levels, but the higher compression you go, the higher the cylinder pressure. Detonation on higher cylinder pressure is a lot more dangerous.
I didn't plan on this post being this long. Basically, it's all up to what you want. Some people boost 10:1 compression because they want decent power out of boost, and some boost lower compression because they want some nasty boost levels.
- Steven